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Out of 287 studies, 24 (1 in 12) were considered to have borderline results when the direction of the primary end point indicated a treatment benefit, with P value between 0.05 and 0.10 or a lower or upper 95% confidence limit close to the no effect value (that is, 1 for risk or hazard ratios and 0 for risk or mean differences). The intention here is not to alter the published conclusions, but only to be aware of the differences in how they were reported. However, a seemingly large effect was found in two trials with P=0.06 and upper 95% confidence limits just above the no effect value (table).
This early benefit persisted (death rate ratio 0.98 (0.92 to 1.04) for additional deaths between day 36 and end of year 10), so that there were 28 (14 to 42) and 23 (2 to 44) fewer deaths per 1000 patients treated with streptokinase after 4 years and 10 years respectively. There was no evidence that absolute survival benefit increased with prolonged follow up among any category of patient, including those presenting early after symptoms started or with anterior ST elevation. Nor did the early benefits seem to be lost in any category (including those aged over 70).
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